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They wanted a small starting group of like-minded north European economies, excluding southern rim states dubbed the "Club Med".
The players pointed out that Boston College had a small starting five when it made its championship run in the conference last season.
With a small starting population of cells, as present in the female mouse embryo around the time XCI is induced, the stochasticity resulted in different outcomes of the choice process for every new calculation.
The risk of GvHD was minimized by a small starting dose based on donor source, conservative dose-escalation by only twofold guided by real-time chimerism response and withholding of DLI instantaneously when the chimerism converted back to 100%.
Here, we develop a novel risk-adapted strategy characterized by pre-emptive DLI initiated at the time of mixed chimerism, a small starting dose based on donor source, dose-escalation guided by real-time chimerism monitoring and withholding of DLI immediately in patients achieving full donor chimerism.
Since it is not possible to determine whether the enrichment shown in Fig. 2A is due to direct conversion of Foxp3– cells or expansion of a small starting population of Foxp3+ cells contained in the sorted CD25− input population, we took advantage of C57BL/6 (B6) Foxp3-GFP reporter mice 33 which allowed us to isolate GFP−/Foxp3− cells by flow sorting.
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That means that there is a lot more growth to come, from a smaller starting point, for today.
It is, therefore, possible that the reduced percentage of Tregs after culture merely resulted from a smaller starting population.
Hearing the word gave us a small start.
It would be a small start, yes, but perhaps significant.
For a small start-up, this is success.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com