A small number of Tbx22 null embryos (2/30) were identified with an overt CP (Fig. 1B).
A small number of such abnormal Runx1-null ER+ ML-like cells may also be present in the ML FACS gate.
Thus, the literature may contain a disproportionately small number of null results.
Instead of a small number of relatively large H3K9Me3 foci, Dicer-null NS nuclei typically contain over twice as many H3K9Me3 foci and these are small and irregular in morphology (Fig. 2F, G), suggesting that Dicer-null NS cells fail to maintain heterochromatin appropriately.
However, simulation studies using data from a network of a small number of monitors have found bias toward the null and wider CIs (Kim et al. 2009).
Our approach is to maintain the overall systematic variation in the high-dimensional dataset, while replacing a small number of observed variables with independently permuted synthetic null variables.
To obtain the parameters of this null distribution, we permute the phenotype (and covariates) a small number of times (e.g. 10) to obtain a null distribution of test statistics.
Another group 23 subsequently studied the same conditional Fbxw7 null mouse, finding a small number of adenomas in the large intestines of homozygous knockout animals at 9 10 months of age.
As only a small number of tested associations were real in our applications, the inclusion of null data generated from these associations introduced a small, conservative bias in our computation of FDR).
However, Niviventer seemed to have a high occurrence of null alleles, with many individuals producing only a small number of sequences, and most other individuals being homozygotes (Table 3).
To perform the separation, frequency-invariant null-steering beamformers, which can work with a small number of microphones, are used.
