Due to its high relevance as a model organism, differences in gene expression under different growth conditions in the same strain have been determined, while a smaller number of analyses have compared different yeast strains [ 2– 5] or species [ 6, 7]. S. cerevisiae was also one of the first species in which transcriptome reconstruction using tiling arrays and RNA-seq was evaluated [ 8– 10].
A small number of secondary analyses based on explicit hypotheses, such as subgroup and explanatory analyses considering compliance with the interventions, will be specified in advance.
Our method to model temporal changes in CCI efficiently captures changes in comorbidity over time with a small number of regression analyses to perform – which would be impossible with tradition time to event analyses.
The main advantage of the proposed approaches is that they allow for a quantification of the effect of uncertainties on the structural capacity, with only a small number of deterministic analyses compared to Monte Carlo simulation.
To date, however, only a small number of systematic analyses address the evolution of physical activity policies.
Despite the recent rapid development of policies to counteract physical inactivity (PI), only a small number of systematic analyses on the evolution of these policies exists.
Our method to model temporal changes in CCI efficiently captures the changes in comorbidity over time with a small number of regression analyses to perform.
It should be noted that only a small fraction of the metabolites in the network are branch points in any given scenario, so that the global network behaviour can be characterised via a small number of detailed analyses.
However, the pattern is very similar to what we observed for the small number of introns (data not shown), so we are convinced that even though data sets B and C contain a small number of introns, analyses based on them are representative.
8 We computed the propensity score by using logistic regression with the dependent variable being receipt of the intervention and the independent variables being the baseline exposures listed in table 2. We also did a small number of sensitivity analyses to examine whether the way the programme was implemented had any effect.
