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A consequence of this from a treatment perspective is that if a sclerostin mAb is dosed with a small dosing interval, and the mesenchymal-derived pre-OB do not have sufficient time to be replenished, the anabolic effect of the mAb will be diminished with repeated doses.
In this context, the assessment of the relationship between dose and systemic exposure was inconclusive, not only due to a lack of PK data within each arm, but also because of large interpatient variability and a small dosing range from 6.5 to 10.0 mg m 2.
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Even a small dose could set off this devastating reaction.
Trouble, at least in a small dose, averted.
Kaletra is formulated with a small dose of Norvir.
"A small dose of ruthlessness" can be useful for a personal brand.
For now, however, that growth provides only a small dose of relief for an ailing industry.
Even a small dose could, in the wrong set of circumstances, kill a user.
A 2.6percentt gain in Japanese stocks yesterday infused American investors with a small dose of optimism.
Could such a small dose, the patient asked, do all this?
Such clarity might finally bring with it a small dose of humility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com