We found that the deletion of SGF73 has a small deleterious effect in glucose limitation (−3.64% ± 0.62) but has an increased fitness of 24.3% in sulfate limitation, demonstrating that the positive fitness effects of this mutation may be specific to sulfate limitation.
It is interesting to note that amlodipine and verapamil showed the same trend, namely a small deleterious effect in WT mice and a much greater accentuation of growth in Marfan mice, with the effect being greater in the ascending aorta than the aortic root.
This is more likely to occur when the absolute cost of hemizygosity is small (long pathways and weak selection), because increasing wild-type enzyme dose will have small effects on flux and small deleterious effects on fitness.
M1a2 would be the youngest clade with a more recent expansion than the others so that purifying selection has not had enough time to eliminate mutations with small deleterious effects in the coding region.
All attempts were made to stain sections as fresh as possible, although storage of whole-frozen and cryopreserved brains at −80°C had smaller deleterious effects and LRRK2 signal could be recovered from brains stored at −80°C for several weeks to months.
The NVCA is correct that an array of Wall Street dynamics, ranging from the investment-banking reforms enacted a few years ago to the shift to trading stocks in penny increments, instead of eighths of a dollar, has had a deleterious effect on small companies trying to go public.
At the time of the invite, my acquaintance peppered me with statements online (fB) suggesting that the impact of delays for employers to participate in Obamacare would have quite a deleterious effect on small businesses; insurance premiums will soar; out-of-pocket caps will exceed $12,500, and that the cheapest plan according to the IRS will exceed $20,000 for a health plan.
The results of other small studies have suggested a deleterious effect of albumin on kidney function, but they had limited statistical power [ 21, 24- 26] or involved very large doses of albumin (more than 1,100 g per patient) [ 24].
In cardiac surgery, a small study suggested that albumin may have a deleterious effect on kidney function [ 21], whereas another found no difference [ 34].
While it is encouraging that in a publicly-funded system only a small proportion of the population was not collecting prescription medication, it is important to note that even small prescription charges can have a deleterious effect on health.
When used prescriptively, a style box has a deleterious effect.
