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The phrase "a slightly different setting" is correct and usable in written English.
It can be used when describing a situation or environment that has minor variations from another.
Example: "In this experiment, we will conduct the tests in a slightly different setting to observe any changes in results."
Alternatives: "a somewhat altered environment" or "a marginally distinct context".
Exact(7)
By now, Mr. Frank was growing so frustrated at seeing so many unsuitable places that this one seemed like a "happy medium in a slightly different setting".
Later Herz [20] gave versions of the spaces defined below in a slightly different setting.
A slightly different setting has been suggested by Van Donselaar, where universities would contribute to the costs.
Systems \(\mathsf{J}, \mathsf{J4}\), and \(\mathsf{JT}\) were first considered in (Brezhnev 2001) under different names and in a slightly different setting.
Infact, in a slightly different setting, [62] quantifies the capacity gains due to a candidate complete-sharing scheduler presented therein, with the caveat that indeed as QoS requirements on real-time traffic become tighter, the opportunistic gain due to complete-sharing diminishes as, eventually, one would need to simply give strict priority to real-time traffic.
A link between RB and E-cadherin was also described in a slightly different setting: E-cadherin-mediated aggregation prevents cell death induced by active PKC.
Similar(53)
More than 300 such accords already exist, each with a slightly different set of rules.
All these things and a myriad more combine to give every person a slightly different set of advantages or disadvantages.
In response, some have proposed the existence of a separate condition – "moral injury" – marked by a slightly different set of symptoms and different causal triggers.
That abstract category sounds absurdly difficult, but it wasn't: it merely required that we ask a slightly different set of questions and grasp a slightly different set of conventions, and, after two or three rounds of practice, guessing the contents of someone's mind fifty miles ago becomes as easy as guessing Winston Churchill.
But the court's opinion last week -- from a slightly different set of justices -- has cast it in a far more favorable light.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com