Exact(4)
A virtual screen of our in-house database using various fingerprint techniques returned several triazine hits which were found to be mTOR inhibitors with a slight selectivity over PI3Kα.
In LP from cells grown on glucose a slight selectivity seems to occur insofar as more unsaturated PE and PC species accumulated compared to the homogenate.
Depsipeptide showed a slight selectivity of about three- to five-fold and apicidin was equally potent against one matched lung cancer/HBEC pair showing no selectivity, but was ∼25-fold specific for cancer in the second pair of lines.
One methyl substituent gives a slight selectivity (1 a and 1 b), which is increased with two methyl substituents (1 c– 1 e), and mesityl salt 1 f gives high selectivity for compound 7.
Similar(56)
Though the biological activities found were generally insignificant to poor, two compounds, one of which possesses a reasonable binding affinity for mGAT1, rac-57, the other a notable inhibitory potency at mGAT4, rac-84, both displaying a slight subtype selectivity for the individual transporters, could be identified.
In general, it has been found that an increase in pressure results in a decrease in overall conversion and a slight decrease in selectivity to isomers with a noticeable increased selectivity to the cyclic products, particularly at the lower temperatures of 210 and 230 °C.
The data confirm the inhibiting effect of K doping on reducibility and catalytic activity, together with a stabilization of the catalytic activity, a reduction of methane selectivity and a slight increase of CO2 selectivity.
The drastic increase in gas permeability was accompanied by only a slight decrease in selectivity.
Conversion increased with temperature almost linearly within the temperature range studied, with a slight decrease in selectivity to formaldehyde.
The inclusion of PIM-1 in the Matrimid matrix results in a substantial increase in gas permeability and a slight decrease in selectivity.
On the other hand, a slight increase of selectivity to the desired product of 3-MeCol can be observed at a higher Fe3O4 loading amount.
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