The phrase "a sizeable blow" is correct and usable in written English.
It can be used to describe a significant impact or setback, often in a metaphorical sense, such as in discussions about challenges or losses.
Example: "The company faced a sizeable blow when their main product was recalled due to safety concerns."
Alternatives: "a significant hit" or "a considerable setback".
As the man chosen to step into Brian O'Driscoll's boots, it is a sizeable blow.
David Silva will be out for three weeks with a knee ligament injury in what is a sizeable blow to Manchester City before Sunday's 168th derby and Wednesday evening's crucial Champions League match with CSKA Moscow.
The third quarter was always going to be crucial so it came as a sizeable blow when Sean Maitland was sent to the sin-bin for a supposedly deliberate knock-on that the referee, Joubert, initially seemed to regard as a simple knock-on.
One of the biggest risks was to the party's own reputation, which suffered a sizeable blow when Lib Dems helped to pass legislation for tuition fees - something they had pledged to oppose in their election manifesto.
They announced Windows Phone 7.8 at the same time, which would bring some functionality from the newer OS to older devices, but the damage it did to existing hardware sales was evident in Nokia's most recent earnings, as it only sold 2.9 million Lumia devices, with its smartphone sales overall taking a sizeable blow.
But it would not take many disappointing auctions for the cost of paying guarantees to blow a sizeable hole in their fragile finances.
Clegg's aides suggested it would be a struggle to reach agreement on all the levies ahead of the autumn statement in December, since the multibillion-pound cost means a simple transfer of the whole cost to the taxpayer would blow a sizeable hole in the government's finances.
"That is a sizeable risk.
The country has a sizeable trade surplus.
And that would be a sizeable whack.
