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The phrase "a sizable suppression of" is correct and usable in written English.
It can be used when discussing a significant reduction or limitation of something, such as rights, information, or resources.
Example: "The government implemented a sizable suppression of free speech during the crisis."
Alternatives: "a significant curtailment of" or "a considerable restriction of".
Exact(1)
The selective antagonist CGP55845 had only minor effects at normal stimulation intensity but produced a sizable suppression of the hyperpolarization elicited by supra-maximal intensity (Fig. 7C).
Similar(59)
The country has a sizable number of his works.
It also offers a sizable selection of 24 fonts.
Umeå University (1965) has a sizable school of medicine.
A sizable fraction of the population are Indians.
Every country has a sizable contingent of mentally ill citizens.
There is also a sizable minority of evangelical Protestants.
There is also a sizable reserve of architectural material.
It also has a sizable collection of modern art.
A sizable list of specials changes weekly.
Tourism is also a sizable source of income.
More suggestions(3)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com