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It is quite obvious that ANA testing on HEp-2 cells outside a proper clinical specialist framework may yield a sizable portion of ANA-positive individuals without consistent evidence of AARD, purportedly leading to inappropriate referrals to tertiary care specialists, as well as anxiety in patients and physicians alike [3] and, perhaps, inappropriate and potentially toxic therapy [6].
Since ANA and related autoantibodies are generally considered useful biomarkers for AARD (which have low prevalences) and are included in the classification criteria for SLE [13], MCTD [14], SjS [15] and SSc [16], ANA testing on HEp-2 substrates outside a proper clinical framework may yield a sizable portion of ANA-positive individuals without consistent evidence of AARD.
In 2008, Taiwan government passed a set of rules designed to achieve a sizable reduction of carbon dioxide (CO2) emissions, namely, "Frameworks of Sustainable Energy Policy".
The elements of Swiss Style, including the use of a grid as a framework for organizing design, would go on to have a sizable impact on the development of graphic design in the mid-20th century.
The special conditions of ground humidity made possible the conservation of wooden frameworks of houses, wooden furniture, the hull of a sizable boat, pieces of cloth, and food (carbonized loaves of bread left within ovens).
That's a sizable victory.
Eaton opened a sizable advantage Wednesday.
"It definitely had a sizable effect".
That's a sizable dating pool.
There is also a sizable Russian population.
There is a sizable Turkish-speaking minority.
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CEO of Professional Science Editing for Scientists @ prosciediting.com