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The phrase "a sizable difference in" is correct and usable in written English.
It can be used when discussing a notable or significant disparity between two or more items, concepts, or measurements.
Example: "There is a sizable difference in the performance of the two models, which affects their overall efficiency."
Alternatives: "a significant difference in" or "a considerable difference in".
Exact(12)
Third, we note that different imputed values can make a sizable difference in the estimated slope and the AIC.
Even a kilogram can make a sizable difference in how much power and range the lithium-ion battery can deliver.
The internet has busied itself finding comparisons between past gen and current gen/next gen (depending on what you're running) locations as shown in trailers for the game today, and there appears to be a sizable difference in terms of texture and lighting.
Anderson's average hit point on the return of serve against Tipsarevic was.26 of a foot inside the baseline while Tipsarevic's was 3.54 feet inside the baseline – a sizable difference in attacking that resulted in Anderson's average second serve return speed being 39 m.p.h. to Tipsarevic's 43 m.p.h.
After controlling for such variables, the findings still showed that exercise made a sizable difference in a student's G.P.A. On a 4.0 grade scale, students who exercised vigorously seven days a week had G.P.A.'s that were, on average, 0.4 points higher than those who didn't exercise.
Though the Forward Backward score function and the SSB method produce comparable results in terms of accuracy, there is a sizable difference in the time it takes to update the weights using these methods.
Similar(48)
A sizable difference for firms with so much in common.
But in Maine, at least, there is a sizable difference between supporting L. L. Bean and supporting Linda Bean.
But technology can make a sizable difference.
One year can make a sizable difference when the ball is almost as big as you.
The lack of a dramatic sustained growth difference in TTR-IGF-I/C57BL/6 TTR-IGF-I/C57BL/6 TTR-IGF-I/C57BL/6nd may reflect a threshord of IGF-I needed to observe a sizable difference.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com