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A fourth prediction of the hypothesis that Rad61 and Elg1-RFC regulate cohesion through a singular mechanism is that rad61 elg1 double mutant cells should exhibit cohesion defects identical to either single mutant strain.
The above finding that elg1 deletion fails to provide any benefit to ctf7 mutant cells beyond those already conferred by rad61 suggests that Rad61 and Elg1-RFC regulate cohesion through a singular mechanism – specifically in opposition to Ctf7 function.
Why would such a singular mechanism have evolved exclusively for Bip1?
From the year 2000, a revolution in the treatment armamentarium of MM has emerged with the availability of new agents with a singular mechanism of action such as thalidomide and lenalidomide, both immunomodulatory drugs, and the proteasome inhibitor bortezomib [ 4].
Similar(56)
It is multifunctional, highly distributed in space, and has an enormous behavioural repertoire; in fact EC dysfunction is not restricted anatomically to a single organ or limited in a singular disease mechanism [ 3, 7].
Thus, the singular mechanism of PKR resistance found in Alphavirus probably reflects a peculiar evolutionary adaptation to vertebrates from arthropods (mainly mosquitoes), the vectors that Alphavirus and other Arbovirus use for transmission [35], [44], [45].
Although no singular mechanism has been identified as the cause of the associations between TB and DM many plausible causal pathways have been suggested.
Examination of the histologic and pathogenic characteristics of these mycobacteria suggests differences in the modes of transmission and pathogenesis, though no singular mechanism for either characteristic has been definitively described for any of these mycobacteria.
The variable stiffness in this design is realized by the prestress stiffness of a cable-based mechanism at a singular configuration.
It is well known that a parallel mechanism at a singular configuration can gain one or more degrees of freedom instantaneously, and at such a configuration it cannot resist externally applied force/torque along certain directions.
Although the transitions referred to so far are of a singular nature, there are other mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com