Even anticipating optimal timing of a single vaccination, optimal vaccine quality and optimal handling of vaccines, some chickens in the flock may not respond optimally to the vaccination due to MDA.
One study showed that a single vaccination, using a vaccine made from multiple VSV filovirus vaccines, affords protection against an otherwise lethal challenge with distinct EBOV species and a MARV isolate (6 ).
In summary, these results suggest that a single vaccination with VLP vaccines can induce antibody secreting plasma cell responses at an early time point post challenge infection.
These results indicate that a single vaccination with an inactivated BRSV vaccine was able to break through the maternal immunity and induce partial protection in very young calves.
From the results described, it can be concluded that, a single vaccination with an inactivated BRSV vaccine was able to break through the maternal immunity and induce partial protection in very young calves.
Limited studies showed 100% protective efficacy in non-human primates after a single vaccination for the chimpanzee Ad3-based vaccine, although a booster immunization was required to achieve long-lasting immunity [ 15].
A single vaccination with A/New Jersey/8/76-based vaccine induced only minimal HI antibody titers in influenza-naive pigs, but existing antibody titers (data not shown) to European avian-like subtype H1N1 SIV in pigs previously infected with this virus dramatically increased, even though these viruses contain HA proteins of the avian and classical swine lineages respectively.
To determine the efficacy of a single vaccination, female Balb/c mice (6 8 weeks) were vaccinated s.c. with 3 µg of sHA or sHA.GCN4pII.
To test whether a single vaccination was sufficient to achieve protection, mice were vaccinated with 80 µg of the RNActive® vaccine encoding HA from PR8. 100% of the vaccinated animals survived, but the temporary weight loss observed in the animals suggested that single vaccination was not sufficient to prevent clinical disease.
Because our previous experiment demonstrated that a single vaccination with 106 IU VRP- neu induced an IgG response, we next vaccinated mice once, twice or three times with 104 IU or 105 IU VRP- neu or the control VRP-HA.
In the experimental lung metastasis model, a single vaccination with Adeno- neu was effective, and the SINCP- neu vaccine was effective when delivered three times at 2-week intervals.
