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An Internet provider was supposed to be providing access to the e-mail of a single target of that investigation, but the F.B.I. soon realized that the filtering controls used by the company "were improperly set and appeared to be collecting data on the entire e-mail domain" used by the individual, according to the report.
Therefore inhibiting a single target of such a network might not lead to the desired therapeutic effect.
With the advent of the Human Genome Project came the industrialisation of the drug discovery process and a belief that combinatorial chemistry and high throughput screening would deliver molecules with increased potency, against a single target of interest.
In addition this connectivity leads to more robust systems that cannot be interfered by the inhibition of a single target of that network and consequently might not lead to the desired therapeutic effect [2].
Data for HbA1c were aggregated to practice level and only referred to the achievement of a single target of ≤7.5%.
For all imprinted genes that influence a single phenotype (that is, a single target of selection), regardless of how these genes influence the trait, the parental origin of expression should be the same within a sex.
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Furthermore, RMCE requires only a single targeting of ESC clones with the acceptor cassette, in general a slow and laborious process.
[7] Still, this corresponds roughly to leaving out a single target out of 14 in the NNRTI set (+/− 10% of target variation).
One of the anomalies negotiated at Kyoto was that the European Union, then consisting of only 15 countries, negotiated a single target for itself of an 8% reduction over 1990 levels.
But Web retailers offer vandals a single target to attack instead of a series of separate stores.
Despite such great efforts, its effect of modifying a single target to improve the production of cellulase is highly limited.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com