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The target identification methods of Barenco et al. [ 18] and Honkela et al. [ 20] are restricted to the case of a single regulating TF.
The methods in [ 18] and [ 20] rank targets by fitting simple linear activation differential equation models for a single regulating TF.
We believe that these precious drugs should be regulated differently from all other drugs and that a single regulating body should be used to license and restrict their use to the most appropriate circumstances in both human and animal health and agriculture.
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"There should be order within Europe and a single regulator that regulates you, not multiple regulators all trying to regulate everything in their own different ways," he said.
Malignant changes such as tumorigenesis or tumor progression are associated with changes in the expression of multiple microRNAs, rather than a single microRNA regulating an oncogene or tumor suppressor target gene [ 26].
Several mechanisms including positive and negative autoregulation, positive and negative feedback and feed forward loops (FFL) could account for deviations from a simple model with a single TF regulating gene expression via a single DNA binding site [ 12].
The identification of regulatory miRNAs and their target mRNAs is a major combinatorial challenge because a single miRNA regulates multiple mRNAs and several miRNAs co-regulate a single mRNA.
This level of detail is omitted here because it does not influence the arguments made in this section; in Sources of noise section, we will, however, treat all of these processes explicitly for the case of a single gene regulated by a single transcription factor.
In most cases, a single miRNA regulated multiple targets.
Breast cancer treatment would be simpler if a single protein regulated a single pathway in all cancer cells.
One of the simplest models of a gene regulatory network consists of a single gene regulated by a self-generated proteomic atmosphere.
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