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For our data, each weight is associated with a single readout of an independent siRNA.
A criticism of this study would be its reliance on a single readout of Akt pathway activation.
HOMA2 yields a single readout of β-cell function and insulin resistance for each subject and has the advantage that, since it only requires paired basal insulin and glucose measurements, it can be used in large epidemiological and pharmaceutical studies.
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IFN-γ has often been used as a single readout for Th1 responses, but recent studies of other infectious diseases have emphasized the importance of polyfunctional T cells co-producing IL-2, IFN-γ and TNF-α [14], [47].
HCS has already proven successful as a method to deliver more relevant information simultaneously in one experiment, rather than delivering a single readout in a series of sequential experiments [ 8– 11].
In contrast, most non-nuclear two-hybrid assays and PCAs rely on a single readout, thereby limiting throughput and increasing the incidence of false positives.
Whereas a simple microarray experiment consists of a single perturbation and readouts for tens of thousands of genes, this screen includes thousands of cDNA overexpression perturbations and a single readout.
Using SUMO foci dispersion as a single-cell readout of host SUMO proteome remodeling, we found that cells expressing actively replicating IAV RNP complexes had significantly fewer SUMO1 and SUMO2/3 foci than cells expressing all the viral protein components of the RNP in the absence of viral-like RNA or mock-transfected cells.
Single readout channel is built of an input AC-coupling circuit with the cut-off frequency below 0.1 Hz, a low noise preamplifier and two parallel band-pass filters with nominal bandwidths from 2 Hz to 100 Hz and from 200 Hz to 2 kHz.
This process may involve augmented Hebbian reweighting, where a single set of readout weights is modified through training on feature differences [ 36].
In the case of susceptibility to both drug classes, the test would indicate susceptibility for each, rather than having a single composite readout specifying XDR-TB.
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CEO of Professional Science Editing for Scientists @ prosciediting.com