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In contrast, most non-nuclear two-hybrid assays and PCAs rely on a single readout, thereby limiting throughput and increasing the incidence of false positives.
IFN-γ has often been used as a single readout for Th1 responses, but recent studies of other infectious diseases have emphasized the importance of polyfunctional T cells co-producing IL-2, IFN-γ and TNF-α [14], [47].
Whereas a simple microarray experiment consists of a single perturbation and readouts for tens of thousands of genes, this screen includes thousands of cDNA overexpression perturbations and a single readout.
For our data, each weight is associated with a single readout of an independent siRNA.
A criticism of this study would be its reliance on a single readout of Akt pathway activation.
HCS has already proven successful as a method to deliver more relevant information simultaneously in one experiment, rather than delivering a single readout in a series of sequential experiments [ 8– 11].
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SFERA is a 16-channels readout ASIC designed in a 0.35μm CMOS technology, which features in each single readout channel a high order shaping amplifier (9th order Semi-Gaussian complex-conjugate poles) and a high efficiency pile-up rejection logic.
Staggered layers of scintillator arrays [6] or of piled arrays of scintillator with different pulse shape (phoswich detector [7]) can be used to obtain the DOI information with a single side readout with a photomultiplier tube (PMT).
In the case of susceptibility to both drug classes, the test would indicate susceptibility for each, rather than having a single composite readout specifying XDR-TB.
Single readout channel is built of an input AC-coupling circuit with the cut-off frequency below 0.1 Hz, a low noise preamplifier and two parallel band-pass filters with nominal bandwidths from 2 Hz to 100 Hz and from 200 Hz to 2 kHz.
Most of the MBONs having dendrites in the α′/β′ and γ lobes provide such a single-layer readout.
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