The EBM, like other data-driven models (Jack et al., 2011; Lo et al., 2011; Bateman et al., 2012; Buchhave et al., 2012; Förster et al., 2012; Landau et al., 2012; Villemagne et al., 2013), assumes that all subjects follow a single progression pattern.
"It would be easier to live with a greater clarity of ambition, to follow goals that beckon toward a single upward progression.
The career that took him from public relations to propaganda to column-writing was a single seamless progression.
Thus, combining them into a single neoplastic progression endpoint may appear nonstringent[15].
Maculopathy can occur at any stage of progression of diabetic retinopathy (11) and therefore cannot be simulated using a single linear disease progression path.
In that study, however, only 160 men were using S.S.R.I.'s, a percentage smaller than in the general population, and the results are based on a single analysis, not progression over time.
When he departed, caught at long-off to give Yuvraj his second wicket, the Proteas still needed 27 to knock India out, but when Peterson gloved Balaji for a single, Pakistan's progression to the last four at their great rivals' expense was confirmed.
Rather than a single event, this progression represents a number of stages of illness, and men and women may progress through these stages differently.
A composite that is restricted to cognitive items in an MCI stage would offer improvement over standard clinical outcomes and would offer the simplicity of measuring a single domain of progression.
Although a number of molecular mechanisms underlying ovarian tumourigenesis have been identified, a single model of progression has not been described, possibly because of the heterogeneous nature of ovarian carcinoma (Shih Ie and Kurman, 2004).
To our knowledge, this is the first report that has identified CK18 and CK8 expression as a single predictor of progression and poor prognosis in OSCC patients after curative resection.
