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A single interim analysis will be performed following completion of 232 angiograms.
A technique is described in which a single interim abutment and crown were fabricated in advance and placed the day of dental implant surgery.
The Phase II design with an option for direct assignment (i.e. stop randomization and assign all patients to the experimental arm based on a single interim analysis (IA) at 50% accrual) was recently proposed [An et al., 2012].
A single interim analysis was conducted at ~47%% of the initially planned overall recruitment (December 2011).
The type-1 error has been adjusted to allow for a single interim analysis based on approximately 45 death events.
The significance level for the primary end point was adjusted for a single interim analysis to 0.025.
Similar(47)
In a single trial, interim analyses increase the risk of type I error.
A single formal interim analysis of the accumulating primary end point data will take place when 70% of the expected events have accrued.
The interim analysis will not influence the final statistical analyses; given the single interim analysis and the stringent stopping criteria, any further adjustment is not considered to be necessary.
A single-center interim open-label Phase II study evaluated the safety and efficacy of canakinumab.
Perhaps the truth lies in further lessons learned, exhibited in the ensuing four presidential searches prior to the current one: Since June 3 , 1933 Princeton has not seen a single day of an interim president, and won't this time either.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com