The phrase "a single functional allele" is correct and usable in written English.
It can be used in contexts related to genetics, specifically when discussing variations of genes that can affect traits or functions.
Example: "In this study, we focused on the impact of a single functional allele on the expression of the disease."
Alternatives: "one active allele" or "a solitary functional allele".
Its potency means that, in heterozygous individuals, a single functional allele is sufficient to maintain its inhibitory function; only homozygous individuals will lack this form of proteolytic regulation.
We performed our analyses in mice that harbour a single functional allele of the AID gene, which results in a reduction of roughly 50% of AID mRNA levels.
In contrast, genes that have experienced strong artificial selection may have retained only a single functional allele.
The patient's father had a lower plasma ACE activity which is related to the presence of a single functional allele.
Thus, a single functional allele for VHL appears to be sufficient to ensure either normality, or at least near normality, for these components of the CP phenotype.
In addition, several systems have been developed that use regulated promoters to control expression of a single functional allele (Samaranayake and Hanes, 2011).
Using primary Drosophila cholinergic neurons we found that loss of a single functional Cam allele suppressed calcium store deficits otherwise observed with the overexpression of FAD-mutant Psn.
Likewise, resting calcium levels in neuronal cultures generated from flies expressing FAD-Psn in cholinergic neurons with only a single functional Cam allele (Cha/Camnull PsnFAD median = 80 nM Ca2+), also appeared normal relative to Cha-GAL4 controls (Fig. 4A).
The observation of less than 50% defective pollen grains in flowers of plants with a single functional P5CS allele indicates that some double mutant pollen was completely degenerated and no longer recognisable when pollen from open anthers was analysed.
We combined both wild-type and heterozygous males for controls because a single functional Dicer allele was sufficient to ensure miRNA processing to wild-type levels, as expected from previous studies (Harfe et al., 2005; Kanellopoulou et al., 2005; Murchison et al., 2005; Chen et al., 2008; Frezzetti et al., 2011).
We combined both wild-type and heterozygous male littermates for the controls because microarray analyses indicated that a single functional Dicer allele was sufficient to ensure miRNA processing to wild-type levels, as expected from previous studies (Harfe et al., 2005; Kanellopoulou et al., 2005; Murchison et al., 2005; Chen et al., 2008; Frezzetti et al., 2011).
