Exact(1)
In our model, we assume that cells can undergo just a single fate transition (black cells turn into blue cells, Fig. 2 a), while for example in stem cells, fate decisions are often binary, i.e. cells have to choose between two mutually exclusive follow-up states.
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During neural development, the differentiated state correlates with sustained expression of a single fate-determination factor.
Since six VPCs are initially equivalent, we hereafter explain modeling operations by using a single VPC fate model as shown in Figure 6 whose six copies are embedded in the whole VPC fate model in Figure 5.
The jolt of electricity effectively fuses man and beast into a single biological fate.
It can turn a youth into an idol, but even if the player dreams of starting and finishing his career in a single club, fate often decrees otherwise.
For many animals, however, including mice and other mammals, there does not exist a single, defined fate map in which the same developmental plan is followed by all individuals of that species.
One important implication of our work is that identifying and reconstructing a "youthful" stem cell niche may have long-term beneficial effects on tissue regeneration, in contrast to drastic modulation of a single cell-fate regulatory pathway, that could have deleterious side effects by promoting oncogenic transformation and/or inducing cellular senescence [ 14].
He attempts to rescue from oblivion a single family's fate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com