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The unified model has a single expression and a maximum of six variables/parameters, whereas in most cases, three to four parameters are sufficient.
Let us require that syntactic rules always apply to a fixed number of expressions and yield a single expression, and let us allow that syntactic rules be undefined for certain expressions.
My purpose is not limited by a single expression, and neither is yours.
For the vertex we do the same but bear in mind the following structure: Both for coefficients and kernels every loop integral is treated as a single expression, and for every equation all loops are grouped into lists.
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Each signature summarizes its constituent genes as a single expression profile, and is here derived as the first principal component of that set of genes (the factor corresponding to the largest singular value) as determined by a singular value decomposition.
Expression levels were assessed using the Robust Multi-array Average algorithm (RMA; [ 25]), which summarizes hybridization signals from multiple probes per gene into a single expression value, and present/absent (P/A) calls were made as described in Methods.
Each signature summarizes its constituent genes as a single expression profile and is here derived as the first principal component of that set of genes (the factor corresponding to the largest singular value), as determined by a singular value decomposition.
These were normalized through a median global array scaling, and a single expression value for each condition was combined from the replicates and associated to a probability of positive log ratio (PPLR) between conditions.
This observation applies to less well-known cases, particularly the attempts to patent models of networks of genes and proteins, which is much more difficult than when patenting a single expression of a gene (Allarakhia and Wensley 2005: 1486).
A standard query is a multi-step process involving an experiment, an experimental factor, and a gene identifier, and returns a single expression value.
The RMA method was used to convert the intensities from the multiple probes of a probe set into a single expression value with greater precision and reduced background noise (relying on the perfect match probes only and thus ignoring the mismatch probes) and then to normalize by sketch quantile normalization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com