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Patients randomized to CCR received their preselected treatment, thus including patients otherwise excluded as poor candidates for a single comparator.
The first results of this prototype demonstrate that the fixed pattern dispersion is reduced below a noise level of 15 e−, allowing the use of a single comparator or a low-resolution ADC per pixel column.
Therefore, a single comparator (Hamming distance) can be quickly used for score matching.
The key weakness was selection of a single comparator study.
When a study included more than one intervention group with a single comparator arm, we included both intervention groups and split the number of patients in the common comparator arm across the separate intervention arms.
They normally compare the incremental cost-effectiveness ratio (ICER) of a new drug that is still under patent to a comparator drug, which may either be a generic or a patented drug at the time of the drug reimbursement submission (for the purpose of this paper, we assumed the existence of a single comparator despite the fact that multiple comparators may exist).
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Also, to assess the robustness of our results to selection of particular control states, we re-estimated models excluding one control state at a time to ensure that no single comparator state was driving the results.
The measurement itself relies on a 1-bit ADC (i.e. a single voltage comparator), and the digitalization of the sensor's response is achieved by a digital clock, which is very effective in terms of extra-power consumption, silicon area and design time, if monolithically integrated with the sensor.
Assumptions of the figure are based on a single common comparator.
The hypothesis of a single temperature comparator assumes that internal temperatures are more or less homogenous which is more likely in endotherms with substantial internal heat production than in 'large' heliothermic (basking) reptiles.
Other limitations included the low number of CV events, the short duration of trials (≤1 y), and a single active comparator (insulin).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com