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Different aspects of protein behavior can be rationalized by studying how the energy landscape of a single chain in the marginally compact phase can be modified.
Depending on the solvents employed, compounds 3 and 4 could be generated, with a 1D bpp-connected Zn bpp Zn double chain that is further hydrogen-bonded into a 2D network that extends parallel to the ac plane in 3, and a single chain in 4.
Despite more domains being defined manually for a single chain in contrast to automated methods, manual definition produced a marginally lower number of polypeptide segments per domain (fig 2b).
FolX crystallised in space group I432, with a single chain in the asymmetric unit.
By extrapolating our simulation results (Fig. 5), we can predict that a diffusion coefficient of 2 μm s 1 would be needed for reliable formation of a single chain (in more than 90% of the cells as observed experimentally).
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The dance may be performed in a closed circle, in a single chain, or in two parallel lines.
The presence of a single chain (as in RN), many chains (as in MN and PBD) or no chains (as in LJC and HCP) does not have an effect on these trends.
It is a single chain polypeptide in plants, bacteria, and mycobacteria, but is part of a complex polypeptide in animals and fungi.
This is congruent with the more general observation that two interacting prokaryotic proteins, not necessarily encoded by neighbouring genes, may be found fused as a single chain homolog in another organism [35], [36], [37].
The electrostatic charges also repel adjacent anionic units along a single chain, resulting in the formation of an extended molecular conformation which consequently leads to the solubilization (Fig. 2b).
This tree was used to prime the Bayesian analysis, which was run in model-jumping mode with a single chain implemented, assessing burn-in (arrival at a likelihood plateau) as described previously [184].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com