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Importantly, a single alteration in a regulatory system component could alter expression of hundreds of genes.
These data suggest that a single alteration in the gene expression profile of the airway epithelium can completely alter the pulmonary response to a normally innocuous aeroallergen.
Perhaps the most egregious mistake I found was a single alteration made to the original Coptic.
A proto-oncogene may be converted into an oncogene through a single alteration of a nucleotide.
A single alteration of history – such as, in Sansom's vision, Lord Halifax rather than Churchill holding sway over the war cabinet in 1940 – can have repercussions all over the globe.
Very few diseases are caused by a single alteration in our genetic code, or what is called a "mutation of the gene".
Similar(37)
One single alteration in a timeline does not necessarily change everything.
However, the reaction with MTSET, placing a positive charge and a bulkier sidechain at this position, also does not completely interfere with channel function indicating that at least in the context of a single domain alteration, this site is reasonably permissive to change (Appendix S1, Tables A and B).
Our methodology can be used to describe dynamics of resistance arising due to a single (epi genetic alteration in any tumor type.
Conversely, balanced chromosome rearrangements were rarely found as a single additional alteration to del (5q).
A single truncating alteration of RPS20 (c.147dupA, RefSeq NM_001023.3) (Supplementary Figure 2 A), a ribosomal protein gene, turned out to be shared by all 4 affected members investigated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com