Addressing these protein interactions would help characterize where oxaliplatin succeeds as a single agent or in combination as well as help understand the underlying mechanisms for its failure.
Multi-agent systems (MAS) consist of multiple intelligent agents that interact to solve problems that may be beyond the capabilities of a single agent or system.
Six trials evaluated ATO as a single agent or in combination with ascorbic acid and ten trials added ATO to other cytostatic agents.
To investigate the efficacy and toxicity of intravitreous melphalan for treatment of retinoblastoma, as a single agent or with concomitant topotecan.
The anticancer potential of these compounds applied as a single agent or in combination with chemotherapeutic drugs is currently being evaluated in preclinical studies and in clinical trials.
A potential of TRAIL as a cancer-specific therapeutic agent has been proposed, either as a single agent or in combination with chemotherapy.
Currently, CPI-613 is being tested in phase I and II clinical trials, as a single agent or in combination with standard chemotherapy, to treat cancers (NCT02168140, NCT01902381, NCT02232152, and NCT01766219).
Chemotherapy agents used to treat cholangiocarcinoma include 5-fluorouracil with leucovorin, gemcitabine as a single agent, or gemcitabine plus cisplatin, irinotecan, or capecitabine.
We used the highest dose of perifosine tolerated by glioma bearing mice as a single agent or in a combination treatment.
Recently, we applied the same technique in patients hospitalized with pneumonia in ICUs and identified Tropheryma whipplei as a single agent or in mixed flora of oral origin [14].
Various agonistic DR5 antibodies such as Conatumumab (AMG655), CS-1008 and Lexatumumab have been currently tested in cancer clinical trials either as a single agent or in combination with other therapeutic agents.
