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The HOPS complex is certainly more than a simple tether, and it remains to be sorted out in detail what "the tethering action of HOPS" involves.
Thus, rather than a simple tether to the DNA, the interaction between Pol III and the clamp is complex, requiring a substantial degree of control.
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Although most scaffolds use a simple tethering mechanism to increase the efficiency of interaction between individual partner molecules, these proteins can also exert complex allosteric control over their partners and are themselves the target of regulation.
In contrast to a simple static tethering model of BicD function, or a role only in initial dynein recruitment to the cargo, our data uncovers a new dynamic role for BicD in actively regulating transport.
This strategy allows for simple tethering of the specific oligonucleotides stabilizing the AgNCs to the nucleic acid probes.
Therefore, we do not think Rab23 fusion confers ciliary localization on receptors by simple tethering.
While some crafty gents over at the Tmo News Forums have cranked out a way to let you use the T-Mobile G1 as a USB modem, it's not exactly the simplest tethering solution we've ever seen.
This interaction is necessary (Stroupe et al., 2006) for tethering of vacuolar membranes, and is sufficient for tethering of proteoliposomes of a simple lipid composition such as PC/PS (Hickey and Wickner, 2010).
The lack of alignment to any specific type of cell-cell junction argues against a simple model of spindle positioning in which the spindle tethers level with the junction.
A simple model holds that LEDGF/p75 directs favored integration into transcription units by tethering.
Mr. Cuarón succeeds by tethering almost unfathomably complex techniques — both digital and analog — to a simple narrative.
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CEO of Professional Science Editing for Scientists @ prosciediting.com