The phrase "a simple mutation of" is correct and usable in written English.
It can be used when discussing a minor change or alteration in something, often in a scientific or technical context.
Example: "The study revealed that a simple mutation of the gene could lead to significant changes in the organism's traits."
Alternatives: "a minor alteration of" or "a slight modification of".
Offspring (candidate layouts) are created legibly through a simple crossover that swaps selected subareas of parental layouts and through a simple mutation that tunes the properties of nodes.
When a single agronomic trait conferred by a specific FNP was favored and selected in early rice intermediates, plants with this FNP would be propagated via migrations and transfers from the plant's original local origin, regardless of whether the FNP originated from selection of a simple mutation or introgression with a locus containing a certain standing variation.
He continued: "This paper brilliantly demonstrates that the genetic basis for our intelligence is not the result of a simple mutation in a single gene.
Of these, close to 8% carry both a simple mutation as a CNV, whereas carriers of only simple mutations or CNVs are almost equally common (43.8% vs. 47.9%).
Because this novel recessive allele cannot be explained by simple mutation of any previously-described dominant alleles, we designate this allele vrs1.a4 (Additional File 7).
Furthermore, natural product variation can be expanded with the simple mutation of the core peptide, or addition and deletion of modification enzymes, leading to a variety of structures and bioactivities within the class.
It is likely that the efficiency of this reaction could be further improved by simple mutation of the Gly and His residues of these Xaa Cys motifs, without loss of bioactivity.
In the simple mutation with rate of p M, for each candidate solution, a random value is selected for each gene and the gene value is altered if the random value is smaller than the mutation rate.
It has been suggested (16, 17) that G2019S may be a simple gain-of-function (GOF) mutation, increasing the rate of phosphorylation of LRRK2 substrates, or it might act as a dominant negative (DN).
The dominant pathogenic role of SIMPLE mutation is further supported by our finding of a CMT1C-like peripheral neuropathy phenotype in transgenic mice expressing SIMPLE W116G mutant and the lack of a neuropathy phenotype in SIMPLE knockout mice.
