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However, overexpression of wild-type DRP1 does not lead to mitochondria fragmentation, suggesting that a simple alteration of DRP1 levels could not alter mitochondrial fission.
Adjustments which may become necessary to adapt the prosthodontic restoration to functional decline should rather be performed by a simple alteration of the denture to minimize the challenges to an elderly person's neuroplasticity and capacity of adaptation.
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The simple alteration of an "A" to 440 hertz--from 432 hertz--has probably had a profound impact that may never be fully realized by most people.
However, simple alteration of the length of a disordered region can also modulate the overall protein function.
Coacervates of varying surface charge were obtained by simple alteration of the PELD:heparin ratio and resulted in diverse release profiles of the model protein bovine serum albumin.
Furthermore, simple alteration of the processing parameters produced microspheres with alternate unique morphologies, such as with solid cores and surface porosity only.
This work demonstrates the feasibility of tuning the solid-state optical properties of fluorescent organic compounds by combining the simple alteration of chemical structure and the physical change of aggregate morphology under external stimuli.
Thus, simple alteration of K+ conductance preceding the surge of inward current can shift the apparent (but not real) range of Nav activation.
The pathogenesis of syringomyelia in Chiari II malformations and other congenital conditions deserves some re-appraisal, as the morphology is not consistent with the effects of simple alterations of fluid dynamics, nor is syringomyelia a late complication here.
Our study illustrates that simple alterations of the regulatory motifs in biochemical networks can have a significant consequence on the response and functionality of these systems.
The term, when applied to thinner, simple alterations of shale-limestone or sandstone-siltstone, has been referred to as minor.
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