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However, these executives are often operating in a silent state of continual overwhelm, and the predictable consequence is disengagement.
Sleep was long regarded as a silent state of the brain because the brain seemingly lacks interaction with the surroundings during sleep.
Using expression data in mouse, we confirm that CpG-rich genes are highly expressed in germline whereas CpG-poor genes are in a silent state.
On the other hand, the upper side of the wedge is determined by the network's falling into a silent state.
And yet our oceans are in a silent state of collapse and need our help.
However, they are operating in a silent state of continual overwhelm, and the predictable consequence is disengagement".
Similar(26)
Epigenetic silencing may therefore better be defined as an epigenetic regulation that maintains a functionally silent state, irrespective of whether it is achieved through a transcription-independent (TGS) or transcription-dependent (PTGS) activity, or a combination of both.
It is viewed as a general translational repressor that maintains mRNPs in a translationally silent state by its ability to bind the 5'cap structure thus displacing the initiation factors eIF4E and eIF4G from these mRNAs [36], [37].
Specifically, in comparing EPRO-derived NETs to corresponding unstimulated neutrophils, we observed an even more striking pattern of PTMs associated with a transcriptionally silent state than for HL-60 cells.
The methylation state of other regulatory sequences with moderate to low CpG density, including promoters and enhancers, shows developmental and/or tissue-specific variations and positively correlates with a transcriptionally silent state [1], [3] [8].
Eventually this accumulation of marks results in a permanently silent state, one that is retained through the mammalian life cycle and is resistant to perturbations such as embryonic demethylation.
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