The phrase "a significantly more stringent" is correct and usable in written English.
It can be used when comparing the level of strictness or rigor of one standard, rule, or requirement to another, indicating that the latter is much stricter.
Example: "The new regulations impose a significantly more stringent set of requirements for safety compliance than the previous ones."
Alternatives: "a considerably stricter" or "a notably tougher".
The Chinese government is preparing to impose minimum fuel-economy standards on new cars for the first time, and the rules will be significantly more stringent than those in the United States, according to Chinese experts involved in drafting them.
The requirements for observing high-mass matter-wave interferometry are significantly more stringent than for the other scientific objectives (non-interferometric tests of quantum physics, testing quantum physics by observing wave-packet expansion).
For our data set, this requirement on HES is significantly more stringent than application of the Bonferroni correction coefficient for multiple testing.
Despite these findings, many clustering algorithms default to significantly more stringent parameters [ CLOBB (Parkinson et al., 2002), with 30 bases at 95% identity, d2_cluster (Burke et al., 1999) with 100 bases at 90% identity, just to name a few].
Because the two very strong gene regulators, 2,4DNT and 2,6DNT have over 2000 genes that were affected, in order to identify most significantly regulated genes, a more stringent false discovery rate (FDR) with adjusted p-value less than 0.002 was applied resulting in 1418 and 1241 significantly differentially expressed transcripts for 2,4DNT and 2,6DNT, respectively.
Defense response (GO 0006952, FDR = 0.047) and chitin metabolism (GO 0006030, FDR = 0.032) were the only processes significantly enriched at a more stringent level (FDR < 0.05).
In order to identify the most significantly influenced pathways in vivo, a more stringent p value (p < 0.002) was applied, which resulted in 1106 significantly regulated transcripts for the in vivo TNT experiment.
We also performed a sensitivity analysis using a more stringent propensity score matching within 0.05.
The initial results of CNVs identified by readDepth were listed in Table 2 and the location information for each of initial CNVs is shown in Additional file 2. For further analysis, we retained only CNVs obtained by a more stringent criterion (RD differed significantly from the average of genome RD; see Methods).
Nevertheless, a discriminating reader may choose to apply a more stringent cutoff of 0.01, in which case calcium signaling would not be a significantly enriched pathway.
