The phrase "a significantly increased recurrence" is correct and usable in written English.
It can be used in contexts discussing the frequency of events, particularly in medical or statistical discussions.
Example: "The study revealed a significantly increased recurrence of symptoms in patients who did not adhere to the treatment plan."
Alternatives: "a notably higher recurrence" or "an appreciably increased recurrence".
Conceptually the association between persistence of symptoms following treatment and subsequent recurrence is particularly straightforward and, indeed, a number of prospective clinical studies have demonstrated significantly increased recurrence rates in patients with such symptoms (e.g., from 25%to7676%) (31,32).
Adjuvant 5-FU has non-significantly increased recurrence free survival (RFS 1.6 yrs. vs. 2.3 yrs.; P = 0.06), however this did not translate into a prolonged overall survival (4.0 vs. 5.0 years; P = 0.09) [ 21].
Women who were non-persistent with treatment had a significantly increased adjusted recurrence OR of 2.88 (95% CI 1.11, 7.46; 8 cases, 14 controls; Table 2) in comparison to women who persisted with treatment.
Women who were non-persistent (⩾180 days without hormonal therapy) had a significantly increased adjusted recurrence odds ratio (OR) of 2.88 (95%CI 1.11, 7.46) compared with persistent women.
High abundance of macrophages in TIF correlated with a significantly increased overall tumor recurrence.
Yin reported that in multivariate analysis, TNBC had a significantly increased likelihood of recurrence within 2 years after surgery rather than thereafter [ 4].
These numbers show a significantly increased risk of recurrence over time with being in the poor prognosis group versus the good prognosis group.
Our analysis demonstrates, firstly that micrometastases can be clearly identified in histologically node-negative patients with vulval cancer and, secondly and more importantly, that women with micrometastases are at a significantly increased risk of recurrence.
Not surprisingly, there is a significantly increased rate of recurrence in T2 tumors relative to T1 tumors and in tumors measuring larger then 5 cm compared to those measuring 3 5 cm [ 6].
In a series of 100 predominantly ER-positive primary breast carcinomas treated adjuvantly with tamoxifen, we demonstrated that in primary cancers with CACNA2D3 CpG methylation, there is a significantly increased risk of recurrence, particularly at visceral sites of liver and lung, whereas there was no increased risk of nodal metastases.
