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The phrase "a significantly higher frequency" is correct and usable in written English.
It can be used when comparing the occurrence of an event or characteristic in one group relative to another, indicating that the frequency is notably greater.
Example: "In the study, we found that participants who engaged in regular exercise had a significantly higher frequency of positive mental health outcomes compared to those who did not."
Alternatives: "a markedly greater frequency" or "a considerably higher rate".
Exact(60)
It has been found that radioactive thymidine gives a significantly higher frequency of aberration than equivalent amounts of radioactive thymine.
The CF group demonstrated a significantly higher frequency of Pseudomonas respiratory infections than the non-CF group.
"In the end, only some subtle physical differences and Alcathoe's distinctive echo-location call, which terminates at a significantly higher frequency than those of its relatives (43-46khz) makes identification possible without genetic analysis".
Methylation of E-cad occurred with a significantly higher frequency in tumors than corresponding normal peritumoral tissues (P < 10−5).
Surprisingly, further analysis revealed that GluN2C KO mice have a significantly higher frequency of mIPSCs compared to WT mice (Fig. 1B, unpaired t-test with Welch's correction, P = 0.0204, n = 11 for WT and 16 for KO).
The FAP-associated desmoids displayed a significantly higher frequency of copy number abnormalities (59%) than the sporadic tumours (37%).
LDR had a significantly higher frequency of X allele (57.7 %) compared to SDR (38.2 %, p < 0.01).
A significantly higher frequency of root surface caries was observed in elderly participants (P < 0.001, OR = 3.80) and ethnic minorities (P < 0.001, OR = 1.93).
Post-hoc comparisons indicate that temperature sensitive patients had a significantly higher frequency of headache in winter than in the other seasons, while temperature non-sensitive patients had a significantly higher frequency of headache in spring (all p < 0.05).
Presently, young females use diversified sources of fashion information with a significantly higher frequency than in the 1990s.
One week later, the rats that received baclofen immediately after training reentered the test chamber with a significantly higher frequency than controls, although no differences in vacillatory responses were observed between groups.
More suggestions(16)
a significantly higher incidence
a significantly higher rate
a significantly higher prevalence
a significantly larger frequency
a far higher frequency
a much higher frequency
a significantly higher recurrence
a significantly higher degree
a dramatically higher frequency
a distinctly higher frequency
a significantly higher range
a markedly higher frequency
a significantly higher quantity
a significantly smaller frequency
a significantly higher valuation
a significantly higher percentage
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com