This number is similar to that found in many empirical studies but in our simulations the loci had significantly higher expected heterozygosity (e.g., Kopps and Sherwin 2012; Kopps et al. 2013; Brown et al. 2014; Crean et al. 2014).
The CBSGs had a significantly lower than expected percentage of genes encoding proteins targeted to the mitochondrion and the ALSGs had a significantly higher than expected percentage (χ2 test, P < 1e-5).
For genotype 1a, a significantly higher than expected proportion of unique variations was observed for E1, E2, NS3/4A, NS5A and NS5B.
However, in a small number of prospectively identified cases with MS who subsequently developed ALS, there was a significantly higher than expected number of C9ORF72 expansions [ 42].
We specifically looked for genes that have not been classified as a driver in CGC and genes that have a significantly higher than expected rank in specific patients.
The GLV-1h68 infection-specific signatures were enriched for up regulated genes associated with immune function with a significantly higher than expected frequency (1.88) according to GeneOntology assignment.
By contrast, there is a significantly higher than expected frequency of SFP sites per nucleotide in non-coding RNA, pseudogenes, and transposons.
Fourteen pairs of motifs co-occurred in a significantly higher than expected number of upstream regions based on the individual occurrences of the motifs, and two pairs had a lower-than-expected co-occurrence.
Among the recombinant MSV genomes obtained using the MatMPCPVW + VWMPCPMat parental viruses, and in the TYLCV data set, we also observed a significantly higher than expected rate of G → T mutations (p = 0.002 and p = 5.2 × 10-7, respectively).
Finally, we detect Smith Lemli Opitz syndrome (SLOS) at a significantly higher than expected rate in all European populations, in Hispanics, and Middle Easterners (1 in 123 from literature vs. 1 in 68 here; 95% confidence interval 1 in 60 78).
