Glycoconjugate vaccines against serogroups A, C, W, and Y exploit the antigenicity of the capsular polysaccharides that characterize the serogroups, but poor immunogenicity of the MenB capsular polysaccharide [ 7] and antigenic diversity of the MenB surface proteins have significantly complicated vaccine development [ 8].
However, at this moment, the high IC50 (half maximal inhibitory concentration) of these compounds and poor pharmacological properties significantly complicate their development for use in the clinic.
This has lead each participant to form the training data and development data in a different way, which has significantly complicated the comparison of the system results on this dataset, since the amount of data used for system training and system tuning is not consistent across participants.
A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs.
On the other hand, the fact that protein folding and trafficking are complex, multistep processes involving multiple cellular targets significantly complicates the task of development of ΔF508-CFTR correctors (Kalid et al, 2010; Pedemonte et al, 2005b).
"Transnistria is essentially experiencing a blockade, which significantly complicate the living conditions for the region's residents," Putin said, according to the Kremlin account.
The appointment of an Iranian would also "significantly complicate" US funding for the IPCC secretariat for that working group.
A complex emergency is a high impact in all of these areas, which significantly complicates all relief and recovery efforts.
Many active pharmaceutical ingredients exhibit a needle-like (acicular) crystal habit, which can significantly complicate their downstream processing.
As a result, the upstream versus downstream reaches differ significantly, complicating this spatial comparison (Table 2).
"Any sanction that compromises Venezuela's ability to pay its debt or pushes it toward default would significantly complicate the wider region," said Sergio Berensztein, an Argentine political analyst.
