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The phrase "a significant workload on" is correct and usable in written English.
It can be used when discussing the amount of work or tasks that are assigned to someone or a group, often implying that the workload is considerable or demanding.
Example: "The new project has placed a significant workload on the team, requiring them to work overtime to meet the deadline."
Alternatives: "a heavy burden on" or "a considerable demand on".
Exact(2)
During a T-piece trial, endotracheal tubes with high resistance can impose a significant workload on the patient's respiratory muscles, which can contribute to weaning failure [ 50, 56, 88].
We chose to study the casualty clinic referrals because a) the largest proportion of acute psychiatric referrals came from the casualty clinic out-of-hours, hence they induced a significant workload on the psychiatric acute departments and b) casualty clinic had less optimal working conditions compared to other sources of referrals.
Similar(58)
Survey promotion and efforts to maximise respondent numbers constituted a significant workload for this PSP.
Acute kidney injury represents a significant workload and economic burden for critical care units.
Consequently, the impact of symptoms on patients' daily lives is one of the most common reasons for consultation for GERD [ 8], which accounts for a significant workload among primary care physicians (PCPs) [ 9].
There was a significant impact on workload, particularly on endoscopy services.
Another major difference between arrays was observed in the overall number of CNVs detected by each platform, which has a significant impact on workload.
All participants were undertaking a significant academic workload.
This can have a significant impact on the workload of a radiological department.
Furthermore, regulatory changes might have a significant effect on administrative workload and costs of purchaser and providers.
Organisational changes in the provision of healthcare services outside CC, such as H@N, have had a significant influence on CC workload and patterns of referrals.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com