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The phrase "a significant work has" is correct and usable in written English.
It can be used when discussing the importance or impact of a particular piece of work, such as a book, research paper, or artwork.
Example: "A significant work has emerged in the field of environmental science, shedding light on climate change."
Alternatives: "an important piece has" or "a notable work has".
Exact(1)
Motivated by an extensive study of classical differential inclusions, a significant work has also been established for fractional differential inclusions.
Similar(59)
"Significant work has been done," he said.
In particular, the significant work has been done (see, e.g., Mao [12], Luo et al. [13]).
Significant work has gone into examining the impact of CBT and PPT administration on student performance.
Significant work has been done on the planning of stand-alone microgrids.
It has been observed that significant work has been done using big data in healthcare sector.
Significant work has been done on formalizing and modeling requirements of such adaptive systems.
"No significant work had been done to the monument in over 110 years.
Nursing chiefs said "significant work" had been done on improvements.
In this connection, it is worth mentioning that in a fuzzy setting, some significant works have been done on fuzzy topological group structure by Foster[9], and Liang and Hai[10] and, in a soft setting, we have worked on soft topological groups[11].
In the meantime, news that usually precedes a significant work stoppage has started to filter in.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com