The phrase "a significant weakness of" is correct and usable in written English.
It can be used when discussing a notable flaw or limitation in a person, system, argument, or product.
Example: "One significant weakness of the proposed plan is its lack of detailed financial projections."
Alternatives: "a major flaw in" or "a critical shortcoming of".
A significant weakness of the SDSA model is the requirement that DSBs originate in the plasmid.
A significant weakness of all analyses to date has been the lack of comparative and comprehensive genomic data from diverse glaucophyte taxa.
It is a significant weakness of the study that we did not determine the kappa coefficient for the multiple assessors (raters) in this particular study.
11 A significant weakness of the study is that it was based in one medical school with a significant 'preclinical/clinical' curricular divide.
A significant weakness of the study, however, is the reliance purely on death certificates alone for cause of death, which were only available for 72% of deaths at the time of analysis.
Starting at two or three days after injection, all CTB-SAP injected mice showed a significant weakness of the hindlimb, although they were still able to walk and perform functional tests.
This trendline had defined key support for this technology exchange-traded fund during the prior month, and an extended trip below this trendline could be a sign of a significant weakness for the sector.
The short-time horizon for our study is therefore a significant weakness to exploring the sustainability of the intervention.
A significant weakness in reconstruction(s) of early coral evolution is that deep-sea corals have been poorly represented in molecular phylogenetic analyses.
A significant weakness is also found because of a combination of PSO and a tabu search technique, and a hybrid of BPSO and a combat GA which do not share probability significance in their processes.
In fact, had the test-retest scores come close to r = 1, this would have suggested that PSCAN was insensitive to measuring change and that would have been indicative of a significant weakness in the test.
