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The phrase "a significant weakening effect" is correct and usable in written English.
It can be used in contexts discussing the impact or influence of something that reduces strength or effectiveness.
Example: "The new policy has a significant weakening effect on employee morale, leading to decreased productivity."
Alternatives: "a considerable diminishing effect" or "a notable reduction effect".
Exact(2)
It verifies that water-temperature has a significant weakening effect on the gypsum, while a much weaker effect from the chlorine ions.
Especially, fluids residing in brittle crust have a significant weakening effect on the mechanics of rocks and affect the long-term structural and compositional evolution of the crust (e.g., Hickman et al. 1995).
Similar(58)
The question is whether the seemingly inevitable pushback will result in a significant weakening in the commitment to compliance.
The latest Royal Institution of Chartered Surveyors (Rics) survey on the housing market has pointed to a significant weakening in expected activity.
But it also revealed a significant weakening of Hollywood's power over the legislation.
The formation of noticeable number of these ultrafine grains within the shear bands could decrease the basal intensity thereby inducing a significant texture weakening effect.
In order to evaluate how significant this weakening effect can be for design purposes, this work aims at quantifying it as a function of various influential parameters.
Further analysis with two additional model materials, pseudo-phosphorene and pseudo-graphene, reveal that the puckered surface can have a significant effect in weakening the materials' ability to disrupt proteins.
The spectre of nuclear war has a curiously weakening effect on superpowers.
The force decreases as the front velocity increases which is a velocity weakening effect.
A motif with a positive (resp. negative) coefficient is thought to have a strengthening (resp. weakening) effect on the binding.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com