The phrase "a significant threat when" is correct and usable in written English.
You can use it to describe a situation or condition under which something poses a notable danger or risk.
Example: "Cybersecurity experts warn that outdated software can become a significant threat when left unpatched for too long."
Alternatives: "a major risk when" or "a considerable danger when".
If your true IP is ever uncovered, it's game over – a significant threat when your adversary owns the infrastructure.
Homegrown radicals only become a significant threat when they are able to connect with militant radical groups with significant experience.
The researchers were of the impression that physicians perceived the EMR as a significant threat when it was used to audit the physicians for documentation and patient confidentiality, for example, "the medical record do regular audit and find out, for example, why the chart has been opened".
From cybersecurity hacks to natural disasters, businesses are faced with significant threats when trying to keep their supply chains under control.
These new entrants, with vast resources, could pose a significant threat to Netflix when it comes to licensing existing content.
According to Masten & Coatsworth [ 45], for resilience to be identified, there needs to be a significant threat to the individual and, when facing such threat, the quality of adaptation or development needs to be good.
The home secretary, Theresa May, described the former transport minister as "unsafe" to run London at a time when we face "a significant threat of terrorism", because of his history of defending extremists when he was a human rights lawyer.
Theresa May, then home secretary, described Khan as "unsafe" to run London at a time when we face "a significant threat of terrorism," because of his history of defending extremists when he was a human rights lawyer, the Guardian reported.
Improvements in public health began significantly reducing rates of tuberculosis even before the arrival of streptomycin and other antibiotics, although the disease remained a significant threat to public health such that when the Medical Research Council was formed in Britain in 1913, its initial focus was tuberculosis research.
This poses a significant threat to public health, not knowing when or where the next pandemic would strike.
Theresa May argued Khan was unfit to be mayor "at a time when we face a significant threat from terrorism".
