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The phrase "a significant theme for" is correct and usable in written English.
It can be used when discussing an important topic or idea that is relevant to a particular subject, work, or context.
Example: "In her novel, the author explores a significant theme for understanding the complexities of human relationships."
Alternatives: "an important theme for" or "a key theme for".
Exact(2)
This is a significant theme for Shaw; it leads on to that of the conflict between man as spiritual creator and woman as guardian of the biological continuity of the human race that is basic to a later play, Man and Superman.
Disappointment in relation to high expectations was a significant theme for "Readers" within their accounts of attitudes towards the treatment (Q 18).
Similar(58)
A significant theme of the table is the role of amorphous solids in applications calling for large-area sheets or films.
"A significant theme of the report is that of staff absence.
Explicit parental anti-smoking socialisation was a more significant theme for non-Indigenous, compared with Indigenous participants (although the majority of non-Indigenous participants were non-smokers).
The effective marketing of PCSGs was a significant theme as several respondents commented on the need for this.
Each chapter focuses on a significant theme -- the arms race and the prospect of global annihilation, for example -- and there are fresh assessments of leaders including Dwight D. Eisenhower, John Paul II and Mikhail Gorbachev.
Nevertheless, it is a significant theme in the linguistic literature.
However, given research classified as 'enterprise' is comprised of diverse applications that address a broad range of topics in manufacturing, it should not be classified as a significant research theme for big data in manufacturing.
Another significant theme that emerged was a need for more guidance from the state about actions hospitals could take with the new data.
It is only odd, perhaps, that it has taken climate change so long to become a significant and controversial theme for the arts.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com