The product required that they overcome significant technical hurdles; it also had an online service component that required high reliability and availability.
Indeed the complexities of getting ChIP-exo to work seemed to be the motivation for developing a derivative of ChIP-exo: ChIP-nexus ("However, we found significant technical hurdles in applying ChIP-exo". PMID: 25751057).
Ford's still keen on its mission of delivering a fleet of self-driving vehicles in operation by 2021, but there remain significant technical hurdles to overcome between now and then.
In recent years, cryo-EM technology is becoming a mainstream technology for structural biology, which is able to potentially overcome the significant technical hurdles in producing challenging proteins such as mammalian Nav channels in sufficient quality and the necessity of crystallization for structural elucidation.
But even if significant technical hurdles can be cleared, fuel cell cars are years away.
Researchers led by Kris Pister are overcoming significant technical hurdles to push the boundaries of robotic miniaturization.
However, oral delivery of protein and peptide drugs faces significant technical hurdles due to the rapid degradation of these drugs by gastric enzymes, the acidic environment, and poor permeation across the intestinal epithelium2.
That group came to the conclusion that, despite more than $1bn worth of investment from the private sector and governments since the 1990s, the Australian geothermal energy sector faced significant technical hurdles, and the prospect of commercial viability before 2030 was slim.
To achieve this, there were several significant technical hurdles to overcome.
This has posed significant technical hurdles for the detection of fetal genetic loci that are not completely absent from the maternal genome using current PCR-based approaches [ 27].
In addition, significant technical hurdles exist when applying the 'omics' tools to single or rare true persister cells or mother cells due to lack of sufficiently sensitive techniques.
