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The term is used widely in a manufacturing context, but it is also applied outside manufacturing in connection with a variety of systems in which there is a significant substitution of mechanical, electrical, or computerized action for human effort and intelligence.
Finally, we filtered the bases where the consensus base was different from the reference base, and if the posterior probability of that consensus base was larger than 1×10−8, it was called a significant substitution.
Of note, we found that those treated received, on average, 22 face-to-face visits, constituting a significant substitution of community for inpatient care.
Gangliosides on L1-cells exhibit a significant substitution of N-glycolyl for N-acetylneuraminic acid (13%) compared to their metastatic sublines and to mutant cells (less than 1%).
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A structurally significant substitution was seen at NS4B position 24 of the human isolate compared with the mosquito and pig isolates from the 1985 outbreak in Thailand.
Nuclear genes also exhibited an overall significant substitution rate acceleration, although much lower in absolute terms than the one experienced by the mt genome.
In the most famous of such devices, incremental repetition, a phrase or stanza is repeated several times with a slight but significant substitution at the same critical point.
We show that there is a small but statistically significant substitution possibility between crude oil and natural gas, but not between crude oil and coal.
Two CnSNPs within Dll4 were observed, including a substitution at G627S predicted to be damaging according to Polyphen analysis due to a significant hydrophobic substitution effect (PSIC score = 1.516).
None of the haplotypes produced a significant allele substitution effect on EBV for SCS or for the production traits (Table 7 or Additional file 1).
None of the three other SNPs was found to have a significant allelic substitution effect when associated with the EBVs for production traits (data not shown) or any significant effect using the regression model (Additional file 1).
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