Of the 17 enhancers and 10 suppressors uncovered by the screen, a significant subset was shown to be capable of affecting Smn-related NMJ phenotypes, validating our approach.
We consider a module to be significant if its significant subset is clustered with no other significant subset in at least 95% of all bootstrap modular descriptions.
To identify the clusters that are significantly distinct from all other clusters, we search for clusters whose significant subset is clustered with no other cluster's significant subset in at least 95% of all bootstrap networks (see Materials and Methods).
Conversely, two clusters are mutually nonsignificant if their significant subsets are clustered together in more than 5% of all bootstrap modular descriptions.
The search for these pairs of modules is straightforward: For each pair of modules, we count in how many bootstrap modular descriptions all nodes in the two significant subsets are clustered together and record this number if it exceeds 5% of all bootstrap modular descriptions (the criterion for nonsignificant modules).
There is a significant subset that is homeless because mental illness leaves them incapable of doing much of the day-to-day business of living beyond finding a place to sleep, something to wear and a little to eat; but for most of those street-dwellers as well, the problem is essentially the same: There is no other place for them to go.
Many secreted proteins will function in general fungal development such as cell wall biogenesis, but a significant subset will be crucial to support the biotrophic life style and hence will be considered virulence factors.
Although the benefits of using statins to effectively control LDL-C and hsCRP levels and to reduce cardiovascular risk are well documented, a significant subset of patients is unable to take full advantage of statin treatment because of muscle pain or weakness, or the risk of increased blood glucose levels.
Recently, we discovered that a significant subset of TNBC is comprised of a new subtype, the claudin-low, which is important because it is biologically distinct from BLBC and has a number of features reminiscent of mammary stem cells [ 1].
A significant subset of FTD is characterized by parkinsonism, an aspect that has been modelled in animals as outlined below.
