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The phrase "a significant shift of" is correct and usable in written English.
It can be used to describe a notable change or transition in various contexts, such as in business, social dynamics, or personal development.
Example: "The company experienced a significant shift of its market strategy to adapt to changing consumer preferences."
Alternatives: "a major change in" or "a considerable transition of".
Exact(60)
The case resulted in a significant shift of power to state courts and helped discourage "forum shopping" by litigants.
In a significant shift of demographics, they began to leave in what experts call a reverse brain drain.
Despite that opposition, however, the war produced a significant shift of power toward Ottawa.
Electing a commissioner who controls the police budget and can dismiss the chief constable is a significant shift of power from the police to the public.
UN-brokered peace talks in Geneva are scheduled to resume in two weeks but are unlikely to do so without a significant shift of policy.
He said the new device "represents a significant shift of thinking of PlayStation as merely a box or console to thinking as a leading authority on play".
A significant shift of high-tech intelligence resources from Iraq to Afghanistan, initiated by Gen. Stanley McChrystal, the former top commander, is also having benefits.
Use of the silver thiosulfate complex results in a significant shift of the silver deposition potential window in the negative direction and highly impeded metal crystallization.
Israel's election represents a significant shift of the country's political centre of gravity to the right - whatever the final shape of the coalition government formed in the next few weeks.
A long-term activist on issues of poverty and justice, Shetty led the movement's international work to end human rights violations and spearheaded a significant shift of the organization's operations to the global south.
The in-situ X-ray photoelectron spectroscopy analysis (XPS, Supplementary Fig. 13) also confirms that the Hads binds strongly on the A-g-C3N4 surface, resulting in a significant shift of the N1s peak.
More suggestions(16)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com