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The phrase "a significant setback to" is correct and usable in written English.
It can be used when discussing an event or situation that has caused a major hindrance or obstacle to progress or success.
Example: "The unexpected storm was a significant setback to the construction schedule, delaying the project by several weeks."
Alternatives: "a major obstacle to" or "a considerable hindrance to".
Exact(46)
The ruling today represents a significant setback to that strategy.
If it's true, it's a significant setback to them".
A league's failure would be a significant setback to the sport in north America.
If the Giants lose Williams for any extended period of time, it will be a significant setback to the secondary.
Still, women's rights advocates said the loss of American funding was a significant setback to the agency.
"It was a significant setback to our team when we learned he would not be able to play".
Similar(14)
Leaders in the midst of recovering from a significant setback need to leverage this moment in time to consider the type of organization they want to be.
An Indian court dealt a significant setback today to the sale of the Enron Corporation's majority interest in a $2.9 billion project of the Dabhol Power Company.
After making the most rapid progress of any region in the world, west and central Africa suffered a significant setback, due to the outbreak which originated in northern Nigeria where immunization campaigns have been suspended since August 2003.
The manager was careful to insist that it was not a significant setback that Kris Boyd decided to return to Rangers rather than explore further the option of a move to Pittodrie, even if signing him would have been a signal of intent.
The attack marks a significant setback for efforts to achieve peace in the region.
More suggestions(24)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com