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The phrase "a significant set of" is correct and usable in written English.
It can be used when referring to a notable or important collection of items, data, or concepts in various contexts.
Example: "The research revealed a significant set of factors that contribute to climate change."
Alternatives: "an important group of" or "a considerable collection of".
Exact(50)
There Cage's writing weaves together an ensemble cast whose choices and interactions cumulatively represent a significant set of potential outcomes.
Last month the CBI questioned the need for a significant set of exams at 16, given the imminent rise of the school leaving age to 18.
During the exchange, one official, Jason Weinstein, wrote, "It's a tricky case, given the number of guns that have walked, but it is a significant set of prosecutions".
"If there are simply a bunch of vague assertions of what might happen -- that is not as compelling as if there were a significant set of understandings to be achieved".
By his death in 1592 he had scrawled in the margins of his copy of the most recent edition a significant set of further revisions, which were printed in a modified form in 1595.
"The Supreme Court's division generates a significant set of disputes about where the boundaries ought to be drawn," he said, "and this case does not -- and explicitly refuses -- to draw the boundary".
Similar(10)
Multinomial attributes coded as sets of dummy variables were retained or excluded on the basis of joint significance, with each level of a jointly significant set of dummies retained regardless of individual significance.
"This has to do with a political current, that involves a pretty significant set of assumptions that technology workers aren't real San Franciscans," Wiener said.
A potentially significant set of results for an Alzheimer's disease treatment boosted shares in Irish biotech company Elan on Tuesday, while its American partner Wyeth also reaped the rewards during New York trading.
A statistically significant set of transcripts was selected using a Benjamini and Hochberg false discovery rate (FDR) of 0.05.
The final factor, one that Mr. Obama's base often overlooks, is that his presidency has produced a more significant set of policies than any Democratic presidency in a half-century.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com