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The phrase "a significant role on" is correct and usable in written English.
You can use it to describe the importance of someone or something in a certain context. For example, "John played a significant role on the team, helping them to win the championship."
Exact(60)
In a battle of extremely low standards, there is one element that seems to be playing a significant role on the final decision of the American people.
It revealed that the hydrodynamic effects played a significant role on the pattern formation and distributions.
Participation of inorganic salts plays a significant role on morphology controllable of intact hollow polypyrrole capsules.
As a senior, Mangino played a significant role on a team that won a Western Pennsylvania Interscholastic Athletic League championship.
Control of compositions and microstructures plays a significant role on developing functionally graded material (FGM).
The ionic strength plays a significant role on the floc size with S880.
The driving force also plays a significant role on adhesion of micro-gears.
The analyses palyses a significant role on C2C12 cells with the large effect of CNTs.
It was found that oil percentage played a significant role on the droplet size and polydispersity.
Froth height plays a significant role on recovery and Fe-grade in the concentrate.
Recent works indicate that the buildings play a significant role on global energy consumption.
More suggestions(16)
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a considerable role on
a prominent role on
a significant relevance on
a large role on
a major role on
a remarkable role on
a huge role on
a significant influence on
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a significant assault on
a significant extent on
a negative role on
a starring role on
a significant message on
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com