The phrase "a significant restructuring of" is correct and usable in written English.
It can be used when discussing changes or modifications to an organization, system, or process that are substantial in nature.
Example: "The company announced a significant restructuring of its management team to improve efficiency and communication."
Alternatives: "a major overhaul of" or "a substantial reorganization of".
Kraft UK's most recent accounts set out details of a significant restructuring of its European operations.
The unprecedented level of the deficit means that a significant restructuring of our economy is inevitable.
Lewis declined to put a figure on potential job losses but admitted: "This is a significant restructuring of a significant-sized business".
For the second time in less than six months, Random House, the world's largest publisher of trade books, announced a significant restructuring of its Crown Publishing Group, the division that produces books by President Obama, Deepak Chopra and Cesar Millan and that will release former President George W. Bush's forthcoming memoir.
WALL STREET JOURNAL Airbus Parent Expected to Alter Investor Base | The New York Times reports: "The board of European Aeronautic Defense and Space, the parent company of Airbus, was expected Monday to announce a significant restructuring of its core shareholder base that would give the German government a direct stake in the group equal to that of France".
"Mathematics is mathematics, and one plus one has to equal two and not five," he said, describing how, even with a significant restructuring of its debt, the Greek government's deficit would still be too large and its economy not competitive enough to put the country back on a sound footing.
As a result, the capital we do have will have to be highly focused resulting in a significant restructuring and streamlining of our business, operations and workforce.
The company is expected to return to profitability this year, thanks to a significant restructuring and cost-cutting program and the layoff of approximately 43,000 workers since 2000.
In the Oligocene, from 25 to 32 million years ago, there was another significant restructuring of the global carbon cycle as grasses evolved a new mechanism of photosynthesis, C4 photosynthesis, and expanded their ranges.
