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The phrase "a significant restraining effect" is correct and usable in written English.
It can be used when discussing the impact or influence of something that limits or restricts actions or outcomes.
Example: "The new regulations have a significant restraining effect on the company's ability to expand its operations."
Alternatives: "a considerable limiting impact" or "a notable constraining influence."
Exact(1)
They also illustrate the epiphyseal tubercle well, both in the anatomical position and at various stages of "epiphyseal slippage", and confirm that it has a significant restraining effect on any tendency of the epiphysis to alter its position relative to the metaphysis.
Similar(59)
Medicare managed care plan spillovers onto FFS Medicare endoscopy utilization changed over time from a significant negative (restraining) effect in the early period to no significant effect by the later period.
In general, H19 has a growth restraining effect and IGF2, a growth promoting effect.
In 1982 Congressional testimony, Mr. Gates said the strategic arms treaties might have had a restraining effect on Soviet military spending.
The connection at each end provides a restraining effect which is beneficial to the compression resistance of the angle members.
However, in concrete, the aggregates have a restraining effect on the shrinkage that takes place within the hydrated cement paste.
Their removal could have a restraining effect on other immune cells, such as T lymphocytes, dendrite cells, or macrophages [ 40– 40].
It demonstrated that EDTA had an obvious restraining effect on metal ions.
In other words, SNAP has a significant "multiplier" effect.
One even showed a significant protective effect.
BlaBlaCar also has a significant network effect.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com